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Tbio
SERPINA5
Plasma serine protease inhibitor

Protein Summary
Description
Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329597
  • ENSP00000333203
  • ENSG00000188488
  • ENST00000553780
  • ENSP00000450837
  • ENST00000554276
  • ENSP00000451610
  • ENST00000554866
  • ENSP00000451126

Symbol
  • PCI
  • PLANH3
  • PROCI
  • PCI
  • PAI3
  • PAI-3
  • PCI-B
  • PROCI
  • PLANH3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
cellular component
0.85
PubMedID
0.67
small molecule perturbation
0.65
tissue sample
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 686.74   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 452   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 686.74   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 452   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0