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Tbio
NUFIP1
Nuclear fragile X mental retardation-interacting protein 1

Protein Summary
Description
Binds RNA. This gene encodes a nuclear RNA binding protein that contains a C2H2 zinc finger motif and a nuclear localization signal. This protein is associated with the nuclear matrix in perichromatin fibrils and, in neurons, localizes to the cytoplasm in association with endoplasmic reticulum ribosomes. This protein interacts with the fragile X mental retardation protein (FMRP), the tumor suppressor protein BRCA1, upregulates RNA polymerase II transcription, and is involved in box C/D snoRNP biogenesis. A pseudogene of this gene resides on chromosome 6q12. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379161
  • ENSP00000368459
  • ENSG00000083635

Symbol
  • NUFIP
  • bA540M5.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
disease perturbation
0.79
cellular component
0.75
transcription factor binding site profile
0.74
virus perturbation
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.37   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.37   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (141)
ZNHIT3
Tbio
Novelty:  0.08389205
p_int:  1
Score:  0.99
Data Source:  BioPlex,STRINGDB
HPCA
Tbio
Novelty:  0.01360155
p_int:  0.999999371
p_ni:  5.69e-7
p_wrong:  6e-8
Data Source:  BioPlex
GRIA2
Tclin
Family:  IC
Novelty:  0.00141257
p_int:  0.999999352
p_ni:  3.77e-7
p_wrong:  2.71e-7
Score:  0.154
Data Source:  BioPlex,STRINGDB
SYN1
Tbio
Novelty:  0.00093242
p_int:  0.999999218
p_ni:  7.82e-7
Data Source:  BioPlex
HIST1H2BL
Tdark
Novelty:  0.64500134
p_int:  0.999999046
p_ni:  9.54e-7
Data Source:  BioPlex
VSNL1
Tbio
Novelty:  0.01221371
p_int:  0.999999004
p_ni:  9.74e-7
p_wrong:  2.2e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
STX1B
Tbio
Novelty:  0.01171833
p_int:  0.999998451
p_ni:  0.000001549
Data Source:  BioPlex
DCLK1
Tchem
Family:  Kinase
Novelty:  0.0064994
p_int:  0.999997478
p_ni:  0.000002522
Data Source:  BioPlex
SNAP25
Tclin
Novelty:  0.00148905
p_int:  0.999993955
p_ni:  0.000003609
p_wrong:  0.000002436
Data Source:  BioPlex
RUVBL1
Tbio
Novelty:  0.0089115
p_int:  0.999991085
p_ni:  0.000008915
Score:  0.723
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
5
2
5
70
lymphocyte count
3
3
3
58.5
high density lipoprotein cholesterol measurement
1
2
2
27.3
IGF-1 measurement
1
1
1
25.8
reticulocyte measurement
3
1
3
21.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
5
70
lymphocyte count
3
58.5
high density lipoprotein cholesterol measurement
2
27.3
IGF-1 measurement
1
25.8
reticulocyte measurement
3
21.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NUFIP1, FMR1 interacting protein 1
VGNC:10472
467271
Mouse
MGI:1351474
27275
Rat
RGD:1359440
364430
Dog
NUFIP1, FMR1 interacting protein 1
VGNC:44039
485458
Horse
NUFIP1, FMR1 interacting protein 1
VGNC:20954
100059457
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NUFIP1, FMR1 interacting protein 1
Mouse
Rat
Dog
NUFIP1, FMR1 interacting protein 1
Horse
NUFIP1, FMR1 interacting protein 1
Publication Statistics
PubMed Score 14.37
PubMed score by year
PubTator Score 7.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title