MAP2
Microtubule-associated protein 2
Protein Summary
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]
- ENST00000199940
- ENSP00000199940
- ENSG00000078018
- ENST00000360351
- ENSP00000353508
- ENST00000361559
- ENSP00000355290
- ENST00000392194
- ENSP00000376032
- ENST00000447185
- ENSP00000392164
- MAP-2
- MAP2A
- MAP2B
- MAP2C
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 0.99 | ||
co-expressed gene | 0.98 | ||
transcription factor perturbation | 0.84 | ||
cellular component | 0.8 | ||
disease | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1648.96 (req: < 5)
Gene RIFs: 67 (req: <= 3)
Antibodies: 1220 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1648.96 (req: >= 5)
Gene RIFs: 67 (req: > 3)
Antibodies: 1220 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 21
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0