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Tchem
KLK5
Kallikrein-5

Protein Summary
Description
May be involved in desquamation. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336334
  • ENSP00000337733
  • ENSG00000167754
  • ENST00000391809
  • ENSP00000375685
  • ENST00000593428
  • ENSP00000471966

Symbol
  • SCTE
  • SCTE
  • KLKL2
  • KLK-L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.66
small molecule perturbation
0.61
cell line
0.58
protein domain
0.58
biological term
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.18   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 326   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.18   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 54
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0