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Tbio
ERO1B
ERO1-like protein beta

Protein Summary
Description
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354619
  • ENSP00000346635
  • ENSG00000086619

Symbol
  • ERO1LB
  • ERO1LB
  • Ero1beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.27   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.27   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
ATP4A
Tclin
Family:  Transporter
Novelty:  0.00008783
p_int:  0.999983719
p_ni:  0.000005008
p_wrong:  0.000011273
Score:  0.191
Data Source:  BioPlex,STRINGDB
FBXO6
Tbio
Novelty:  0.02173918
p_int:  0.999810089
p_ni:  0.000189911
Score:  0.29
Data Source:  BioPlex,STRINGDB
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.997997024
p_ni:  0.002002976
Data Source:  BioPlex
ERO1A
Tbio
Novelty:  0.01022914
p_int:  0.994468516
p_ni:  0.005531484
Score:  0.899
Data Source:  BioPlex,STRINGDB
LYZL2
Tdark
Family:  Enzyme
Novelty:  0.50542161
p_int:  0.993150797
p_ni:  0.006849203
Data Source:  BioPlex
HEPACAM2
Tbio
Novelty:  0.19192547
p_int:  0.972290463
p_ni:  0.027709536
Data Source:  BioPlex
ERP44
Tbio
Novelty:  0.02352693
p_int:  0.955610986
p_ni:  0.044389014
Score:  0.632
Data Source:  BioPlex,STRINGDB
RLN1
Tbio
Novelty:  0.03992636
p_int:  0.928188836
p_ni:  0.071183176
p_wrong:  0.000627988
Data Source:  BioPlex
LY86
Tbio
Novelty:  0.00314575
p_int:  0.90956703
p_ni:  0.089607598
p_wrong:  0.000825372
Data Source:  BioPlex
LCN6
Tbio
Novelty:  0.11406686
p_int:  0.904670515
p_ni:  0.095184973
p_wrong:  0.000144512
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Insulin processing (R-HSA-264876)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insulin processing
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Name
Explore in Pharos
Explore in Source
Insulin processing
Metabolism of proteins
Peptide hormone metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
76.2
C-reactive protein measurement
3
2
3
60.1
autoimmune thyroid disease
1
1
0
1.1
59.8
1
1
1
22.8
cortical surface area measurement
1
1
0
5.9
19.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
76.2
C-reactive protein measurement
3
60.1
autoimmune thyroid disease
0
1.1
59.8
1
22.8
cortical surface area measurement
0
5.9
19.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endoplasmic reticulum oxidoreductase 1 beta
VGNC:533
469720
Mouse
MGI:1914725
67475
Fruitfly
FBgn0261274
38500
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endoplasmic reticulum oxidoreductase 1 beta
Mouse
Fruitfly
Publication Statistics
PubMed Score 13.27
PubMed score by year
PubTator Score 8.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title