DGKZ
Diacylglycerol kinase zeta
Protein Summary
Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity (PubMed:11257115). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Activates PIP5K1A activity via generation of phosphatidic acid (PubMed:15157668). The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]
- ENST00000318201
- ENSP00000320340
- ENSG00000149091
- ENST00000343674
- ENSP00000343065
- ENST00000421244
- ENSP00000391021
- ENST00000454345
- ENSP00000412178
- ENST00000456247
- ENSP00000395684
- ENST00000527911
- ENSP00000436291
- ENST00000532868
- ENSP00000436273
- DAGK6
- DAGK5
- DAGK6
- DGK-ZETA
- hDGKzeta
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.96 | ||
transcription factor | 0.86 | ||
protein domain | 0.85 | ||
transcription factor perturbation | 0.74 | ||
metabolite | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 105.38 (req: < 5)
Gene RIFs: 37 (req: <= 3)
Antibodies: 204 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 105.38 (req: >= 5)
Gene RIFs: 37 (req: > 3)
Antibodies: 204 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0