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Tclin
AGTR1
Type-1 angiotensin II receptor

Protein Summary
Description
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349243
  • ENSP00000273430
  • ENSG00000144891
  • ENST00000404754
  • ENSP00000385612
  • ENST00000461609
  • ENSP00000418851
  • ENST00000474935
  • ENSP00000418084
  • ENST00000475347
  • ENSP00000419783
  • ENST00000497524
  • ENSP00000419422

Symbol
  • AGTR1A
  • AGTR1B
  • AT2R1
  • AT2R1B
  • AT1
  • AG2S
  • AT1B
  • AT1R
  • AT1AR
  • AT1BR
  • AT2R1
  • HAT1R
  • AGTR1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.94
biological process
0.91
biological term
0.86
disease
0.85
disease perturbation
0.74


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3181.46   (req: < 5)
Gene RIFs: 587   (req: <= 3)
Antibodies: 457   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3181.46   (req: >= 5)
Gene RIFs: 587   (req: > 3)
Antibodies: 457   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 618
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12
Approved Drugs (12)
1 – 10 of 12
losartan
Rendered image for losartan
telmisartan
Rendered image for telmisartan
olmesartan medoxomil
Rendered image for olmesartan medoxomil
candesartan cilexetil
Rendered image for candesartan cilexetil
irbesartan
Rendered image for irbesartan
saralasin
Rendered image for saralasin
angiotensin II
Rendered image for angiotensin II
eprosartan
Rendered image for eprosartan
valsartan
Rendered image for valsartan
azilsartan medoxomil
Rendered image for azilsartan medoxomil
Active Ligands (618)
1 – 10 of 618
CHEMBL4128926
Rendered image for CHEMBL4128926
CHEMBL372814
Rendered image for CHEMBL372814
CHEMBL278176
Rendered image for CHEMBL278176
CHEMBL4435800
Rendered image for CHEMBL4435800
sparsentan
Rendered image for sparsentan
CHEMBL346728
Rendered image for CHEMBL346728
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
angiotensin II receptor type 1
VGNC:8802
460762
Macaque
angiotensin II receptor type 1
712773
Mouse
MGI:87965
11608
Mouse
MGI:87964
11607
Rat
RGD:2070
24180
Species
Name
OMA
EggNOG
Inparanoid
Chimp
angiotensin II receptor type 1
Macaque
angiotensin II receptor type 1
Mouse
Mouse
Rat
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P30556-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (46)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Clathrin-mediated endocytosis
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Class A/1 (Rhodopsin-like receptors)
Clathrin-mediated endocytosis
G alpha (q) signalling events
GPCR downstream signalling
Protein-Protein Interactions (441)
1 – 10 of 441
SLC6A8
Tbio
Family:  Transporter
Novelty:  0.00332655
p_int:  0.996384147
p_ni:  0.003093631
p_wrong:  0.000522223
Score:  0.265
Data Source:  BioPlex,STRINGDB
ATP2B3
Tbio
Family:  Transporter
Novelty:  0.00901493
p_int:  0.993567254
p_ni:  0.006432746
Score:  0.299
Data Source:  BioPlex,STRINGDB
TMEM11
Tbio
Novelty:  0.00067837
p_int:  0.983876701
p_ni:  0.006456061
p_wrong:  0.009667238
Score:  0.181
Data Source:  BioPlex,STRINGDB
CAV1
Tbio
Novelty:  0.00035244
p_int:  0.973462949
p_ni:  0.003961724
p_wrong:  0.022575327
Score:  0.664
Data Source:  BioPlex,STRINGDB
DCX
Tbio
Novelty:  0.00077614
p_int:  0.965093826
p_ni:  0.034906107
p_wrong:  6.7e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
ATP2B4
Tbio
Family:  Transporter
Novelty:  0.00560356
p_int:  0.957738566
p_ni:  0.042261434
Score:  0.235
Data Source:  BioPlex,STRINGDB
SLC19A2
Tbio
Family:  Transporter
Novelty:  0.00761796
p_int:  0.95278141
p_ni:  0.04721851
p_wrong:  8e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
p_int:  0.903324787
p_ni:  0.096675213
Score:  0.221
Data Source:  BioPlex,STRINGDB
TSPAN15
Tbio
Novelty:  0.16947672
p_int:  0.902697687
p_ni:  0.082322131
p_wrong:  0.014980182
Score:  0.189
Data Source:  BioPlex,STRINGDB
AGT
Tbio
Novelty:  0.00049613
Score:  0.996
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  3181.46

PubMed score by year
PubTator Score  2825.27

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer